What can be a consequence of an external institution overruling an IRB approval?

When an external institution overrules an IRB approval, research may be able to proceed without the oversight that the IRB originally provided. This means that the protective measures and ethical considerations established by the IRB may not be in effect anymore, potentially leading to ethical risks for participants. An external institution's decision can create a scenario where the necessary checks and balances that an IRB provides are circumvented. This raises ethical concerns because one of the primary functions of an IRB is to safeguard the rights and welfare of research participants. Hence, the implication of research proceeding without the intended oversight is significant, as it may lead to inadequate protections for participants involved in the study.